Evidence-Based
The Science Behind Your Cellular Age
Published research on NAD+ decline, sirtuin biology, and why your cells age
The NAD+ Decline
NAD+ — the coenzyme powering 500+ metabolic reactions — declines approximately 10–25% per decade from your 30s onward. By age 60, cumulative reductions of 40–60% impair DNA repair, mitochondrial energy production, and the sirtuin enzymes that regulate aging.
Massudi et al., 2012; Camacho-Pereira et al., 2016
Sirtuins — Your Longevity Regulators
The 7 sirtuin enzymes (SIRT1–7) regulate DNA repair, inflammation control, and mitochondrial biogenesis. Every sirtuin requires NAD+ as a consumed co-substrate. In animal studies, boosting sirtuin activity extends lifespan and reverses multiple aging markers.
Imai & Guarente, 2014; Kanfi et al., 2012
CD38 — The NAD+ Destroyer
CD38, an enzyme on immune cells with ~100× higher NADase activity than any other consumer, is the primary driver of age-related NAD+ decline. Chronic inflammation upregulates CD38, creating a vicious cycle: inflammation depletes NAD+, depleted NAD+ impairs inflammation control.
Chini et al., 2020; Covarrubias et al., 2020
Why IV, Not Oral
Oral NAD+ precursors (NMN, NR) face variable bioavailability — partially degraded by gut enzymes and subject to liver first-pass metabolism. Clinical trials show oral NR increases blood NAD+ by ~100% at 1000mg/day. IV NAD+ delivers the molecule directly into circulation.
Airhart et al., 2017; Trammell et al., 2016
All claims are supported by peer-reviewed research cited above. This is educational content, not medical advice.
NAD+ levels drop roughly in half between age 40 and 60
“NAD+ IV is the most direct restoration protocol in clinical use today. See your cellular age before you decide on a dose protocol.”See my cellular age
How The Scan Works
From Scan To Drip Match In 2 Minutes
Before you book, see your biological age. The report tells you which IV protocol is the right fit — so you're not paying for a drip you don't need.
1. Scan
Answer 8 questions in 2 minutes. No cameras, no blood, no labs.
2. Report
Get your biological age score plus a breakdown by body system — skin, immune, cellular, metabolic.
3. Drip match
Your report recommends the exact IV protocol matched to your scores. Book the consultation with the report in hand.
What's in Your NAD+ IV Drip?
Every NAD+ infusion pairs the active coenzyme with the co-factors that help your cells spend it on repair — not on clearing oxidative damage.
Cellular Currency
NAD+
C₂₁H₂₇N₇O₁₄P₂
Pure Nicotinamide Adenine Dinucleotide — the coenzyme every cell needs for ATP production, DNA repair, and Sirtuin activation.
Bio-age Marker
Direct substrate replacement for the co-enzyme that halves between age 40 and 60.
Cellular Optimisation
NAD+ IV Drip Benefits at Our London Clinic — In Bio-Age Units
What our patients see on re-scan after a NAD+ loading course plus maintenance.
Cellular Energy
- Cellular age markers improve within 3–6 sessions in our patient data.*
- Energy and cognitive clarity — downstream of mitochondrial ATP cycling.*
- Morning energy returns within the loading course for most patients.*
- Afternoon crashes resolve as mitochondrial output stabilises.*
Cognition & Recovery
- Brain fog lifts within 1–3 sessions in most patient reports.*
- Word-recall and processing speed track with mitochondrial output.*
- Post-viral and post-illness recovery timeline compresses.*
- Exercise tolerance and recovery rebuild across the series.*
Longevity Markers
- Sleep and recovery — NAD+ is a substrate for circadian regulators.*
- Sirtuin activation drives DNA-repair capacity on the bio-age axis.*
- Inflammation markers decline as oxidative load drops.*
- Cellular-age gap closes toward — and sometimes below — chronological.*
*Representative outcomes based on anonymised patient data; individual results vary.
Is a NAD+ IV Drip Right For You?
Three cellular-age profiles that see the biggest change from a NAD+ IV loading course.
Persistent fatigue
Low cellular NAD+ manifests as fatigue that rest doesn't fix. Your mitochondria are running on depleted substrate — every ATP cycle requires NAD+, and from age 40 onward levels drop ~50%.
What this IV reverses
- Restores mitochondrial NAD+ substrate
- Accelerates ATP production per cycle
- Morning energy returns within loading course
- Resolves the 3pm crash for most patients
NAD+ IV vs NAD+ Supplements
NAD+ IV vs Standard Vitamin Drips & Oral Supplements
NAD+ supplements and generic IV drips can't reach therapeutic doses. Here's why a physician-led NAD+ IV infusion works where NMN, NR, and oral NAD+ precursors don't.
“Standard vitamin drips provide raw materials; NAD+ therapy recharges the very engines that use those materials.”
Bespoke NAD+ IV Protocol
From Scan to Visible Results in 4 Steps
A physician-led protocol — not a one-size-fits-all NAD+ push.
Scan
2-minute cellular age assessment. No cameras, no labs.
Report
Your cellular age score plus energy/mitochondrial markers and drip-match recommendation.
Consultation
Our GMC-registered doctor reviews your report and tailors the NAD+ protocol.
Drip session
Administered slowly (90-120 min typical for NAD+) in clinic by a specialist nurse.
Transparent NAD+ IV Pricing
How Much Does a NAD+ IV Drip Cost in London?
NAD+ IV therapy from £395 per session. All prices include a free consultation with our GMC-registered doctors.
Includes free biological age report (£149 value)
2–3 hours · Private suite
- Full NAD+ infusion
- Cellular energy boost
- DNA repair activation
- GMC-registered doctor
- Comfortable private suite
Prices include VAT. Klarna, Clearpay and Ideal Finance (interest free up to £1,000) available for courses.
NAD+ IV Results — Real Patient Outcomes
Every cell is unique. These are real patient outcomes from our clinics.
James · 54
Senior law-firm partner · 18+ months fatigue · brain fog · normal GP bloodwork
Cellular Age
Years Recovered
Clinical Protocol
- Advanced NAD+ IV Drip × 8 sessions over 10 weeks (loading: 4 sessions / 10 days, then fortnightly)
- Glutathione + high-dose Vitamin C added from session 3
- Re-scan at week 10 to reassess cellular age
Outcome
By session 3, big gains in morning energy and mental clarity. Re-scan at week 10 put cellular age at 55 — within one year of chronological. Now on monthly maintenance.
"I'd been told for years my fatigue was just stress. Watching my cellular age drop from 62 to 55 on the re-scan was the single best proof point — the number moved, not just how I felt."
— James, 54 — NAD+ Patient
NAD+ IV Drip Reviews — What Our Patients Say
Real patients. Verified on Google. Read what they had to say.
“Genuinely life-changing.”
I came to Harley Street Wellness as a last resort after 2 years of chronic fatigue. I'd been bounced between GPs and specialists with no answers. After just 3 NAD+ sessions, the brain fog I'd been living with started to lift. By session 5 I was waking up with energy I hadn't felt since my twenties. The team didn't just treat me — they actually listened.
Flexible Payments
Invest in Yourself
Achieving your wellness goals shouldn't be a financial burden. We offer seamless payment options tailored to your lifestyle.
Pay in 3
Spread the cost over 3 interest-free instalments. No fees, no interest.
Pay in 4
4 equal payments, due every 2 weeks. Always interest-free.
Loans over £500
Interest free up to £1,000. Flexible medical loans with fast decisions.
Wellness Experts
Meet Your Harley Street NAD+ Doctors
Our NAD+ IV drip protocols are administered exclusively by GMC-registered doctors specialising in NAD+ therapy, regenerative medicine, and functional wellness.

Dr. Ahmad
Medical Director
GMC Registered · Aesthetic & Regenerative Medicine
Dr. Ahmad is the founder and Medical Director of Harley Street Wellness. With extensive experience in aesthetic and regenerative medicine, he leads our team in delivering exceptional patient care and innovative treatment protocols.

Dr. Humaira Faisal
Wellness Physician
GMC Registered · Metabolic Health & Integrative Medicine
Dr. Humaira specialises in metabolic health and personalised wellness programmes. Her integrative approach combines conventional medicine with nutritional and lifestyle interventions for optimal patient outcomes.

Dr. Ayda Soltanzadeh
Wellness Consultant
GMC Registered · Wellness & Vitality Optimisation
Dr. Ayda Soltanzadeh is a Wellness Consultant with several years of experience in optimizing patient health and vitality through personalized wellness strategies.

Dr. Mazhar Khan
Wellness Consultant
GMC Registered · 23 Years Clinical Experience
Dr. Khan is a Wellness Consultant with 23 years of clinical expertise, dedicated to delivering comprehensive and personalized care to his patients.
Established Clinical Standards
Clinical Rigour. London's Harley Street NAD+ Clinic.
Harley Street Wellness is a dedicated NAD+ clinic built on the principle that true wellness starts at the cellular level. Our physician-led NAD+ IV therapy, Myers Cocktail, Methylene Blue, and advanced infusion protocols are delivered by GMC-registered doctors across our London and Glasgow clinics.
NAD+ IV FAQs
NAD+ IV London FAQs — Cost, Near Me, Side Effects & Safety
Everything you need to know about NAD+ IV therapy, NAD+ infusions, and NAD+ treatment at our London and Glasgow clinics.
Our NAD+ IV Drip is £395 per session (2–3 hours). A typical loading course is 4 sessions over 10 days followed by monthly maintenance — your doctor will confirm your personalised plan at the free consultation. Payment plans via Klarna and Clearpay are available, and medical financing exists for courses over £500.
We share the exact clinic address after your assessment — which lets us match you to the nearest of our UK locations based on the postcode you provide during the assessment. All NAD+ IV infusions are administered on-site in a private treatment suite by our specialist IV nurses under continuous medical supervision — no at-home service, by design (see safety below).
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell — it's fundamental to mitochondrial ATP production, DNA repair, and Sirtuin activation (the 'longevity genes'). NAD+ IV therapy delivers pure NAD+ directly into your bloodstream, bypassing the digestive system for 100% bioavailability — something no oral supplement can match.
Yes, for a clinical effect. Oral NAD+ precursors (NR, NMN) must pass through your digestive system where absorption is limited to 5–15% — and they still require conversion in the body. IV NAD+ bypasses the gut entirely, delivering the active coenzyme straight to your cells. If you're looking for noticeable changes in energy, clarity, and recovery within days, IV is the only route that delivers the required therapeutic dose.
NAD+ infusions are longer than standard vitamin drips — typically 2–4 hours — because NAD+ must be infused slowly to be comfortable and effective. Most patients bring a laptop or book and treat it as a recovery day.
For general wellness and anti-aging: 4–6 initial sessions followed by monthly maintenance. For chronic fatigue or brain fog: 6–10 sessions over 4–8 weeks. For post-viral recovery (e.g. Long COVID): a loading course of 5 sessions then bi-weekly maintenance. Our doctors create a personalised plan at your free consultation.
NAD+ IV therapy has a well-established safety profile and is administered at our clinic under continuous medical supervision by GMC-registered doctors. Mild flushing, warmth, or chest tightness during the infusion can occur and resolves immediately when the infusion rate is adjusted. Your full medical history and medications are reviewed before any treatment is recommended.
We deliberately do not offer at-home NAD+ IV. NAD+ must be infused slowly under medical monitoring — flushing, transient blood-pressure changes, and rate adjustments are routine and need a clinical environment to be safe and comfortable. Our UK clinic offers private, comfortable suites specifically designed for this.
Key benefits patients report: sustained energy without caffeine, clearer cognitive function, improved sleep quality, better recovery from exercise and illness, reduced inflammation, and anti-aging effects driven by Sirtuin and PARP activation (the enzymes responsible for DNA repair and cellular maintenance).
Yes — this is one of the most consistent patient reports. Your brain uses 20% of your body's energy. When NAD+ is depleted, neurons are ATP-starved, which manifests as brain fog, slow word recall, and mental fatigue. Restoring NAD+ often produces noticeable clarity improvements within 1–3 sessions.
NAD+ activates Sirtuins — a class of proteins that regulate DNA repair, stress resistance, and cellular longevity. Natural NAD+ levels drop ~50% between age 40 and 60, which is directly linked to accelerated cellular aging. Restoring NAD+ through IV therapy is one of the few evidence-backed interventions that directly targets this pathway.
Yes — our doctors often build combined protocols. Common pairings: NAD+ with Glutathione (enhanced antioxidant support), NAD+ with high-dose Vitamin C (immune and recovery), and NAD+ with Myers Cocktail on alternating weeks. Your doctor will advise what's appropriate for your goals.
Your biological age score, a breakdown by body system (skin, immune, cellular, metabolic), and a specific IV-protocol recommendation.
It's based on validated survey instruments our clinical team adapted from peer-reviewed biological-age research. It's a screen, not a diagnostic blood test — but it's the starting point every patient at our clinic goes through.
No. The scan and the report are free, regardless of whether you book a drip afterwards.
No. The report is yours to keep. Most patients use it to decide whether the drip they were considering is actually the right fit.
Clinic Locations
Visit Our Clinics
Three UK locations across London and Glasgow — our team will match you to the nearest clinic after your free assessment.

Harley Street
10 Harley Street, London W1G 9PF

Chancery Lane
London Medical Rooms, Ground Floor, 1–5 Portpool Lane, London EC1N 7UU

Glasgow Day Surgery Centre
154 Clyde Street, Glasgow G1 4EX
GMC-registered doctors · London & Glasgow · No obligation
The information on this page is provided for educational and informational purposes only and does not constitute medical advice. Individual results may vary. All consultations and treatments are carried out by GMC-registered doctors at our clinics.
© 2026 Harley Street Wellness. All rights reserved.

